TANDY

(Torsion Angle approach to Nucleic acid Distance geometrY)

• TANDY provides a fast means of generating a family of DNA structures, consistent with NMR distance constraints.
• TANDY takes explicit advantage of the chemical structure and connectivity of the given sequence of DNA to derive information on the torsion dependence of interatomic distances.
• TANDY's fast-minimization algorithm is ideal for interactive use in conjunction with other complementary algorithms (such as those used for spectral simulation, energy minimization and molecular dynamics calculations).
• TANDY's fast zip-up algorithm is efficient in minimizing double-stranded DNA structures, and its torsion space algorithm ensures unbiased sampling of the conformational space.
• TANDY uses fixed sugar geometry in each nucleotide during minimization.

• Click Here to view the TANDY Brochure

Example of 2 strand DNA sequence created with TANDY.



(Tandy output files were converted to PDB format via Tandy and then displayed)

Hardware Requirements

• Silicon Graphics workstations (Irix 5.x & 6.x)

TANDY References