CONTRAST, version 2.0

CONTRAST

Automated Assignment Tools for Peptides and Proteins

CONTRAST

Requires the amino acid sequence and the NMR peak coordinates in the form of chemical shifts and intensities from 2D, 3D and nD peak lists generated by SpecManPlus to perform automated assignment of peptides and proteins.
Generates Customizable procedures based on the input data for extracting connectivities and completing assignments.

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Assigned Peaks in HCCHT, HNCA, HNCO & HNCAB

Provides the user with several versatile tools for manipulating peak lists in order to design a custom strategy.
Works with any type of multidimensional NMR spectral data to generate the best set of resonance assignments. Based on the quantity and quality of input data, CONTRAST provides only partial assignments.
Enables easy viewing and editing of peak lists and assignment tables.
Exports results as ASCII files compatible with typical 'spreadsheet' format.

Results of Automated Assignment

Applications

Automated sequential assignment of peptides and protein NMR data.

Academic Origin

CONTRAST was developed by Drs. John Markley and John Olson, Jr. at the National Magnetic Resonance Facility located at the University of Wisconsin-Madison. All rights, title, and interest in CONTRAST are owned by the Wisconsin Alumni Research Foundation ('WARF'). The commercial version of CONTRAST has been exclusively licensed to Spectrum Reseach, LLC by WARF.